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In this paper the authors investigated wound repair in gastric mucosal cells treated with hepatocyte growth factor and the protein kinase inhibitor Genistein. Hepatocyte Growth Factor Accelerates The Wound Repair Of Cultured Gastric Mucosal Cells. Sumio Watanabe, Miyoko Hirose, Xian-En Wang, Kohei Maehiro, Toshio Murai, Osamu Kobayashi, Akihito Nagahara and Nobuhiro Sato. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS Vol.199, No. 3, 1994 Effects
of hepatocyte growth factor (HGF) on gastric wound repair were assessed.
Artificial wounds of uniform size were made by mechanical
cell denudation in confluent rabbit gastric mucosal cell sheets.
The changes in wound size were analyzed quantitatively.
The wound repair process contained an initial migration stage
and a later proliferation stage.
The wound was completely repaired in 36 h in controls; this
repair was accelerated by HGF with the induction of cell migration
followed by proliferation and was retarded by tyrosine protein kinase
inhibitor genistein. HGF
might play some roles in gastric ulcer healing. |